Organizing and advocacy from the grassroots, champions within national governments, and recently implemented legal reforms have made the Latin American region an important focus for academic and activist engagement with disability rights issues. Bringing the critical insights of a social model of disability and a rights-based perspective to the issue of employment and employability, we outline a general landscape of factors influencing social and economic inclusion of people with disabilities, drawn from primary field interviews conducted with attendees of computer training centers for people with disabilities, participants in an intensive wheelchair mobility training course, and disability rights advocates and policy-makers in Mexico, Guatemala, Venezuela, and Ecuador.