Antibacterial drug combinations and evolution of drug resistanceRemy Chait, Harvard Systems BiologyThe rapid evolution of bacterial drug resistance and the alarming slowdown in development of new antibiotics is spurring attention towards multi-drug treatments. But how do such treatments affect the rate of evolution of drug resistance? I will present a simple model and direct experimental measurements showing that non-additive interactions between the drugs can profoundly alter the fitness landscape, leading to surprising and counterintuitive outcomes. Please refer to OpenWetWare for more information.
The Synthetic Biology Engineering Research Center (SynBERC) is a multi-institution research effort to lay the foundation for synthetic biology, which aims to build biological components and assemble them into integrated systems to accomplish specific tasks. Watch SynBERC events, like talks in the Seminar Series, online here! Because of the collaborative and distributed nature of the consortium, many events are both streamed for live teleconferencing and digitally archived online (here at blip.tv) for later viewing. This includes talks in Seminar Series, which features seminar-type presentations given by luminaries in the field on topics relating to synthetic biology, and occassionally more informal lunchtime roundtable discussions. Please visit the Seminar Series page on OpenWetWare for the current schedule.